The physical French midfielder was substituted in the defeats to Tottenham and Newcastle and was also not in action on the win over Huddersfield on Saturday but he seemed in good spirit in training at Carrington on Tuesday.
United boss Jose Mourinho has a lot of big names on the injury list since the F.A cup win at Huddersfield and trained with the other fit players before travelling to Spain.
Pogba and Mourinho in recent weeks have not had a good relationship after the pair had a heated conversation on the touchline at Wembley before Pogba was replaced against Spurs.
It then emerged that the player spoke for an hour in Mourinho’s office at Carrington on Tuesday and Pogba is said to have left that meeting looking less than impressed.
Pulled from the cup tie due to illness it did little to help the suggestions that the player and manager’s relationship has become strained over where he is being played in the side.
But with the Champions League approaching on Wednesday, both got down to business as United plot to win the biggest club honour in European football.
Goalkeeper David Gea is set to return to the side after being rested on Saturday but Pogba has been described by Mourinho as doubtful for the game in Spain as the Portuguese remains coy on his team selection.
January signing Alexis Sanchez is the biggest boost for Mourinho with the Chile ace eligible for the competition as he did not feature in Europe for previous club Arsenal.
Marcos Rojo, Phil Jones and Marouane Fellaini are the confirmed absentees and are not expected to play any part in Spain.
Striker Marcus Rashford, Ander Herrera and Antonio Valencia meanwhile do have a chance of recovering from injury to play in Spain, with all three taking part in Tuesday’s training session.
The injuries to defenders Rojo and Jones mean the return of Eric Bailly, who came on as a late substitute at Huddersfield, is timely ahead of the knockout rounds.
United are the last British side to play their first leg in the last-16 and they will have seen Liverpool and Manchester City record thumping away wins to all but guarantee a place in the quarter-finals.
jurgen Klopp’s side hit Porto for five while City put Basle to the sword and left Switzerland comfortable 4-0 winners.
And with United last winning the Champions League trophy in 2008 – and Mourinho with Inter Milan in 2010 – the Red Devils will be eyeing a strong run to the latter stages of this year’s tournament.